Biochemie der Ernährung | Prof. Dr. Stefan Lorkowski - Publikationen (Zeitschriftenbeiträge)

Ruptierte arteriosklertoische Plaque aktiviert die Blutgerinnung

Biochemie der Ernährung

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Prof. Dr. Stefan Lorkowski

 

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Biochemie der Ernährung  >>  Institut für Ernährungswissenschaften  >>  Friedrich-Schiller-Universität Jena

 

 

 

 

 

   

 

 

 

 

 

 

 

 

 

Publikationen

 

Zeitschriftenartikel

 

 

 

2011

 

Maeß, M.B., Buers, I., Robenek, H., Lorkowski, S.
Improved protocol for efficient non-viral transfection of premature THP-1 macrophages.
Cold Spring Harbor Protocols 2011; 2011(5):508-511.

PMID: 21536764; PDF document

 

Rauch, U., Saxena, A., Lorkowski, S., Rauterberg, J., Durbeej-Hjalt, M., Hultgårdh-Nilsson, A.
Laminin isoforms in atherosclerotic arteries from mice and man.
Histology and Histopathology 2011; 26(6):711-724.

PMID: 21472686; PDF document

 

Lorkowski, S.
Chemistry meets nutrition - Toward a systems biological description of human metabolism.
Pure and Applied Chemistry 2011; 83(1):151-165.

PDF document

Supplementary material is available here.

  

 

2010

 

Maeß, M.B., Sendelbach, S., Lorkowski, S.
Selection of reliable reference genes during THP-1 monocyte differentiation into macrophages.
BMC Molecular Biology 2010; 11(1):90.

PMID: 21122122; PDF document

Supplementary material is available here.

 

Lorkowski, S.
RASL11B (RAS-like, family 11, member B).
Atlas of Genetics and Cytogenetics in Oncology and Haematology 2010; 14(4):747-750.

PDF document

  

 

2009

 

Beetz, N., Harrison, M., Brede, M., Zong, X., Moura, E., Lorkowski, S., Viera-Coelho, M. A., Hamet, P., Gaudet, D., Kotchen, T., Kaldunski, M., Nüsing, R., Biel, M., Coley, A., Stoll, M., Lohse, M. J., Broeckel, U., Hein, L.
Phosducin controls stress-dependent blood pressure in mice and human.
Journal of Clinical Investigation 2009; 119(12):3597-3612.

PMID: 19959875; PDF document

A corrigendum is available here.

 

Lorkowski, S., Rauterberg, J., Harrach-Ruprecht, B., Troyer, D.
Collagen-bound LDL modifies endothelial cell adhesion to type V.
Central European Journal of Biology 2009; 4(4):536-542.

PDF document

 

Schnoor, M., Buers, I., Sietmann, A., Brodde, M.F., Hofnagel, O., Robenek, H., Lorkowski, S.

Efficient non-viral transfection of THP-1 cells.

Journal of Immunological Methods 2009; 344(2):109-155

PMID: 19345690; PDF document

 

Robenek, H., Buers, I., Hofnagel, O., Lorkowski, S., Severs, N.J.
GFP-tagged proteins visualized by freeze-fracture immuno-electron microscopy: a new tool in cellular and molecular medicine.
Journal of Cellular and Molecular Medicine 2009
; 13(7):1381-1390.

PMID: 18624750; PDF document
 

Buers, I., Robenek, H., Lorkowski, S., Nitschke, Y., Severs, N.J., Hofnagel, O.
TIP47, a lipid cargo protein involved in macrophage triglyceride metabolism.
Arteriosclerosis, Thrombosis and Vascular Biology 2009; 29(5):767-773.

PMID: 19286631; PDF document

 

 

2008

 

Tölle, M., Pawlak, A., Schuchardt, M., Kawamura, A., Tietge, U.J., Lorkowski, S., Keul, P., Assmann, G., Chun, J., Levkau, B., van der Giet, M., Nofer, J.-R.

HDL-associated lysosphingolipids Inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production.

Arteriosclerosis, Thrombosis and Vascular Biology 2008; 28(8):1542-1548.

PMID: 18483405; PDF document

 

Schmidt, A., Bilgasem, S., Lorkowski, S., Vischer, P., Völker, W., Breithardt, G., Siegel, G., Buddecke, E.
Exogenous nitric oxide regulates activity and synthesis of vascular endothelial nitric oxide synthase.
European Journal of Clinical Investigation 2008; 38(7):476-485.

PMID: 18578689; PDF document

 

Schnoor, M., Cullen, P., Lorkowski, J., Stolle, K., Robenek, H., Troyer, D., Rauterberg, J., Lorkowski, S.
Production of type VI collagen by human macrophages: a new dimension in macrophage functional heterogeneity.
Journal of Immunology 2008; 180(8):5707-5719.

PMID: 18390756; PDF document

 

Broadbent, H.M., Peden, J.F. Lorkowski, S., Goel, A., Ongen, H., Green, F., Clarke, R., Collins, R., Franzosi, M.G., Tognoni, G., Seedorf, U., Rust, S., Eriksson, P., Hamsten, A., Farrall, M., Watkins, H., for the PROCARDIS consortium.
Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked, SNPs in the ANRIL locus on chromosome 9p.
Human Molecular Genetics 2008; 17(6):806-814.

PMID: 18048406; PDF document

 

Lorkowski, S.

The ins and outs of lipid efflux.

Journal of Molecular Medicine 2008; 86(2):129-134.
PMID:
18084736; PDF document

 

 

2007

 

Lorkowski, S., Rauterberg, J., Harrach-Ruprecht, B., Troyer, D.

Collagen-bound low density lipoprotein modifies endothelial cell adhesion to type V collagen: Implications for atherosclerosis.

Nature Precedings 2007; 1-4.

PDF document

 

Stolle, K., Schnoor, M., Fuellen, G., Spitzer, M., Cullen, P., Lorkowski, S.

Cloning, genomic organization, and tissue-specific expression of the TGF-β1 inducible RASL11B gene.

Biochimica et Biophysica Acta 2007; 1769(7-8):514-524.

PMID: 17628721; PDF document

 

Uehara, Y., Miura, S., von Eckardstein, A., Abe, S., Fujii, A., Matsuo, Y., Rust, S., Lorkowski, S., Assmann, G., Yamada, T., Saku, K.

Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsible element.

Atherosclerosis 2007; 191(1):11-21.

PMID: 16730733; PDF document

 

Lorkowski, S., Cullen, P.

Atherosclerosis.

Encyclopedia of Life Sciences 2007; 1-11.

PDF document
 

Hofnagel, O., Buers, I., Lorkowski, S., Schnoor, M., Robenek, H.

Expression of perilipin isoforms in cell types involved in atherogenesis (Letter).

Atherosclerosis 2007; 190(1):14-15.
PMID: 16842797; PDF document

 

 

2006

 

Xie, Q., Engel, T., Schnoor, M., Niehaus, J., Hofnagel, O., Buers, I., Cullen, P., Seedorf, U., Assmann, G., Lorkowski, S.

Cell surface localization of ABCG1 does not require LXR activation.

Arteriosclerosis, Thrombosis and Vascular Biology 2006; 26(11):e143-144.

PMID: 17053170; PDF document

 

Robenek, H., Hofnagel, O., Buers, I., Robenek, M.J., Lorkowski, S., Schnoor, M., Heid, H., Troyer, D., Severs, N.J.

Butyrophilin controls milk fat globule secretion.

Proceedings of the National Academy of Sciences of the USA 2006; 103(27):10385-10390.

PMID: 16801554; PDF document

Supplementary material is available here.

 

Schmidt, A., Lorkowski, S., Seidler, D., Breithardt, G., Buddecke, E.
TGF-β1 generates a specific multicomponent extracellular matrix in human coronary smooth muscle cells.

European Journal of Clinical Investigation 2006; 36(7):472-482.

PMID: 16796604; PDF document

 

Lott, P.-L., Mundry, M., Sassenberg, C., Lorkowski, S., Fuellen, G.
Simplifying gene trees for easier comprehension.

BMC Bioinformatics 2006; 7(1):231.

PMID: 16643669; PDF document

Supplementary material is available here.

TreeSimplifier is available here.

  

Spitzer, M., Lorkowski, S., Cullen, P., Sczyrba, A., Fuellen, G.
IsoSVM – Distinguishing isoforms and paralogs on the protein level.
BMC Bioinformatics 2006; 7(1):110.

PMID: 16519805; PDF document

Supplementary material is available here.

IsoSVM is available here.

 

 

2005

 

Fuellen, G., Spitzer, M., Cullen, P., Lorkowski, S.

Correlation of function and phylogeny of ABC proteins based on an automated analysis of 20 model proteomes.
Proteins: Structure, Function, and Bioinformatics 2005; 61(4):888-899.

PMID: 16254912; PDF document

Supplementary material: here.

 
Stolle, K., Schnoor, M., Fuellen, G., Spitzer, M., Engel, T., Spener, F., Cullen, P., Lorkowski, S.

Cloning, cellular localization, genomic organization, and tissue-specific expression of the TGFβ1-inducible SMAP-5 gene.

Gene 2005; 351:119-130.

PMID: 15922870; PDF document

Supplementary material is available here.

 

Robenek, H., Robenek, M.J., Buers, I., Lorkowski, S., Hofnagel, O., Troyer, D., Severs, N.
Lipid droplets gain their PATs by interaction with specialized plasma membrane domains.
Journal of Biological Chemistry 2005; 280(28):26330-26338.

PMID: 15897193; PDF document

 

Cignarella, A., Engel, T., von Eckardstein, A., Kratz, M., Lorkowski, S., Lüken, A., Assmann, G., Cullen, P.
Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptors

Atherosclerosis 2005; 179(2):229-236.

PMID: 15777536; PDF document

 

Robenek, H., Lorkowski, S., Schnoor, M., Troyer, D.
Spatial integration of TIP47 and adipophilin in macrophage lipid bodies.
Journal of Biological Chemistry 2005;
280(7):5789-5794.

PMID: 15545278; PDF document

 

 

2004

 

Stolle, K., Weitkamp, B., Rauterberg, J., Lorkowski, S., Cullen, P.

Laser-microdissection-based analysis of mRNA expression in human coronary arteries with intimal thickening.

Journal of Histochemistry and Cytochemistry 2004; 52(10); 1511-1518.

PMID: 15505346; PDF document

 

Hofnagel, O., Lüchtenborg, B., Stolle, K., Lorkowski, S., Eschert, H., Plenz, G., Robenek, H.

Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells.

Arteriosclerosis, Thrombosis and Vascular Biology 2004; 24(10):1789-1795.

PMID: 15271788; PDF document
 

Lorkowski, S., Cullen, P.

The ABC of cholesterol efflux and high-density lipoprotein formation.

Current Opinion in Lipidology 2004; 15(5):611-613.
PMID: 15361799; PDF document

 

Schnoor, M., Voß, P., Cullen, P., Böking, T., Galla, H.-J., Galinski, E. A., Lorkowski, S.

Characterization of the compatible solute homoectoine as a potent PCR enhancer.

Biochemical and Biophysical Research Communications 2004; 322(3):867-872.

PMID: 15336543; PDF document

  

Seedorf, U., Engel, T., Lüken, A., Bode, G., Lorkowski, S., Assmann, G.

Cholesterol absorption inhibitor ezetimibe blocks uptake of oxidized LDL in human macrophages.

Biochemical and Biophysical Research Communications 2004; 320(4):1337-1341.

PMID: 15303279; PDF document

 

Engel, T., Lüken, A., Bode, G., Hobohm, U., Lorkowski, S., Schlüter, B., Rust, S., Cullen, P., Pech, M., Assmann, G., Seedorf, U.
ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export.
FEBS Letters 2004; 566(1-3):241-246.
PMID:
15147902; PDF document

 

Lorkowski, S., Cullen, P.

High-throughput analysis of mRNA expression: microarrays are not the whole story.

Expert Opinion on Therapeutic Patents 2004; 14(2):377-403.
PDF document
 

Spitzer, M., Fuellen, G., Cullen, P., Lorkowski, S.

VisCoSe: Visualization and Comparison of consensus Sequences.

Bioinformatics 2004; 20(3):433-435.

PMID: 14752005; PDF document

VisCoSe is available here.

 

Lorkowski, S., Cullen, P.

High-density lipoprotein cholesterol levels and cholesterol efflux – a missing link?

Current Opinion in Lipidology 2004; 15(1):81-84.
PMID:
15166813; PDF document

 

 

2003

 

Lorkowski, S., Cullen, P.

The ABC of cholesterol efflux and high-density lipoprotein formation.

Current Opinion in Lipidology 2004; 15(5):611-613.
PMID: 15361799; PDF document

 

Fuellen, G., Spitzer, M., Cullen, P., Lorkowski, S.
BLASTing proteomes, yielding phylogenies.
In Silico Biology 2003; 3(3):313-319.
PMID:
12954093; PDF document
Supplementary material is available here.

  

Lorkowski, S.
Differentielle Genexpression humaner Makrophagen während der Schaum­zell­bildung.
BIOspektrum 2003; 9(3):56-57.
PDF document
 

Lorkowski, S., Cullen, P.

High-density lipoprotein cholesterol levels and cholesterol efflux – a missing link?

Current Opinion in Lipidology 2004; 15(1):81-84.
PMID:
15166813; PDF document

 

 

2002

 

Lorkowski, S., Cullen, P.
Apolipoprotein E – from Lipids to plaque stability.
Current Opinion in Lipidology 2002; 13(6):689-692.
PMID:
12441893; PDF document
 
Cullen, P., Baetta, R., Bellosta, S., Bernini, F., Chinetti, G., Cignarella, A., von Eckardstein, A., Exley, A., Goddard, M., Hofker, M., Hurt-Camejo, E., Kanters, E., Kovanen, P., Lorkowski, S., McPheat, W., Pentikäinen, M. Rauterberg, J., Ritchie, A., Staels, B., Weitkamp, B., de Winther, M.
Rupture of the atherosclerotic plaque: does a good animal model exist?
Arteriosclerosis, Thrombosis and Vascular Biology 2002; 23(4):535-542.
PMID:
12615660; PDF document
 
Uehara, Y., Engel, T., Li, Z., Göpfert, Ch., Rust, S., Zhou, X., Langer, C., Schachtrup, Ch., Wiekowski, J., Lorkowski, S., Assmann, G., von Eckardstein, A.
Polyunsaturated fatty acids and acetoacetate down-regulate the expression of the ATP binding cassette transporter A1.
Diabetes 2002; 51(10):2922-2928.
PMID:
12351428; PDF document
 

Bellosta, S., Bernini, F., Chinetti, G., Cignarella, A., Cullen, P., von Eckardstein, A., Exley, A., Freeth, J., Goddard, M., Hofker, M., Kanters, E., Kovanen, P., Lorkowski, S., Pentikäinen, M., Printen, J., Rauterberg, J., Ritchie, A., Staels, B., Weitkamp, B., and de Winter, M.
Macrophage function and stability of the atherosclerotic plaque: Progress report of a European project.
Nutrition, Metabolism and Cardiovascular Diseases 2002; 12(1):3-11.
PMID:
12125228; PDF document

 

Lorkowski, S., Cullen, P.
Subfamily G of the ATP-binding cassette transporter protein family.
Pure and Applied Chemistry 2002; 74(11):2057-2081.

PDF document

 
Cullen, P., Lorkowski, S.
Peroxisome proliferator-activated receptor γ still full of surprises.
Current Opinion in Lipidology 2002; 13(3):335-337.

PMID:
12045403; PDF document

 

Cullen, P., Lorkowski, S.
DNA microarrays in medicine.
Expert Opinion on Therapeutic Patents 2002; 12(12):1783-1794.
PDF document
 

  

2001

 

Cullen, P., Lorkowski, S.
Anwendungen der DNA-Arraytechnologie in der Laboratoriumsmedizin.
Journal of Laboratory Medicine 2001; 25(11/12):469-476.
PDF document
 
Engel, T.*, Lorkowski, S.*, Lüken, A., Schlüter, B., Berger, G., Cullen, P., Assmann, G.
The human ABCG4 gene is regulated by oxysterols and retinoids in human monocyte-derived macrophages.
Biochemical and Biophysical Research Communications 2001; 288(2):483-488.
*Both authors contributed equally to this manuscript.
PMID:
11606068; PDF document

Von Eckardstein, A., Langer, C., Engel, T., Schaukal, I., Cignarella, A., Reinhardt, J., Lorkowski, S., Li, Z., Zhou, X., Cullen, P., Assmann, G.
ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages.
FASEB Journal
2001
; 15(9):1555-1561.
PMID:
11427487; PDF document

Lorkowski, S., Kratz, M., Wenner, C., Schmidt, R., Weitkamp, B., Fobker, M., Reinhardt, J., Rauterberg, J., Galinski, E.A., Cullen, P.
Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease.
Biochemical and Biophysical Research Communications 2001
; 283(4):821-830.
PMID:
11350058
; PDF document

Wenner, C., Lorkowski, S., Engel, T., Cullen, P.
Apolipoprotein E in macrophages and hepatocytes is degraded via the proteasomal pathway.
Biochemical and Biophysical Research Communications 2001; 282(2):608-614.
PMID: 11401504; PDF document

Cullen, P., Lorkowski, S.
Biochips – Diagnostik in der Streichholzschachtel.
MTA Dialog 2001; 2(1):4-8.
PDF document
 
Lorkowski, S.
Differentielle Genexpression humaner Makrophagen während der Schaum­zell­bildung.
Klinische Chemie – Mitteilungen 2001; 32(3):72-75.
PDF document

 

Lorkowski, S.*, Rust, S.*, Engel, T., Jung, E., Galinski, E. A., Assmann, G., Cullen, P.
Genomic sequence and structure of the human ABCG1 (ABC8) gene.
Biochemical and Biophysical Research Communications 2001; 280(1):121-131.
*Both authors contributed equally to this work.
PMID:
11162488; PDF document
 

Lorkowski, S., Cullen, P.
DNA-Computer – Arbeitet der Rechner von morgen mit DNA anstatt mit Silizium?
KlinBiol 2001; 4:13-19.
PDF document
 

 

2000

 

Lorkowski, S., Ellinghaus, P., Galinski, E. A., Assmann, G., Cullen, P.
Use of longer extension phases to improve product yield in differential display PCR.
Clinica Chimica Acta
2000
; 299(1-2):199-204.
PMID:
10900305; PDF document

 

Lorkowski, S.
Printing with DNA.
Chemistry in Britain 2000; 36(10):22.
PDF document

 

Lorkowski, S., Lorkowski, G., Cullen, P.
Biochips – Das Labor in der Streichholzschachtel.
Chemie in unserer Zeit 2000; 34(6):356-373.

PDF document
 
Lorkowski, S., Cullen, P.
Computertechnologie von morgen – DNA statt Silizium?
BIOspektrum 2000; 6(4):277-279.

PDF document
 
Lorkowski, S., Cullen, P.
Der Computer von morgen – DNA statt Silizium?
Journal of Laboratory Medicine 2000; 24(6/7):310-313.

PDF document
 
Cullen, P., Lorkowski, S.
Gene, Chips und Bits. Die nächste Generation der Labordiagnostik.
Roche Dialog 2000; 1:21-24.

PDF document

 

 

 

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Institut für Ernährungswissenschaften

Friedrich-Schiller-Universität Jena
Dornburger Str. 25
07743 Jena
 

Telefon-Nr.+49 3641 9-49710

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Stefan Lorkowski | 2008-2011

 

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